Transcript
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A listener.
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Production doctor Ginny Mansburg is an easily recognized name and
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face if.
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You are from Australia.
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She's a GP in Sydney who also has an extensive
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media career spanning decades. You would have no doubt seen
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her on Channel seven's Sunrise, Embarrassing Bodies down Under on
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Channel nine, or Medicine or Myth on THEESBS. She's also
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voted Australia's most trusted health professional in twenty twenty two.
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She hosts a bunch of her own podcasts. She's written
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a bunch of books, the most recent of which is
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called Save Your Brain, and that is what I am
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talking to her about in today's episode.
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Most of us have.
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Been touched in some way by dementia, and in fact,
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Ginny shares that in twenty twenty two to fifty five
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million people around the globe we're living with dementia. Most
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of us are worried about our loved one, but we're
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also really concerned about our own risk of.
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Developing this disease.
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The good news is that there are things that we
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can do to save our brains, and the time to
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do those things is in our forties, fifties and sixties.
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I could not wait to dive into this with Ginny
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and get the answers to the question how do we
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save our brains? Here is that conversation, Doctor Jenny Mansburg.
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Welcome to the Crappy to Happy Podcast.
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Love being Crappy to Happiness.
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So good, Ginny.
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I was so excited to see the book that you
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have just written all about how to save your brain
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and I couldn't wait to get you on the show
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to talk about it. So I think all of us
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have been touched by dementia, Like everybody that you speak
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to has a parent, a parent and in law a
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grandparent who has experienced dementia. I don't know if it
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is suddenly more I'd spread that it has been before,
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if we're just suddenly more aware of it.
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Can you tell me what is the prevalence of dementia
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the moment?
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Well, the moment, it's the second biggest killer of Australians
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and the biggest killer of women. So it does affect
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four times as many women as men, and of course
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it goes up the older you are and when living longer,
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which is why we're seeing so much more of it
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because Australians in particular you know, and also people all
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over the West world. We are living so much longer,
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and with that, of course increases the odds of getting dementia.
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But it's the biggest cause of death in women, and
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a lot of people don't realize it causes death. It
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actually is a fatal disease.
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Yeah, that's a scary, scary thing. And you talked about
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in the book something like I don't have it off
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the top of my head. You'll know it. Thirty something
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percent of eighty five year old will have dementia.
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Absolutely, and then double that number will have what we
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call mild cognitive impairment. So it's slight in scale, and
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when you hit enough kind of brain loss or brain failure,
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which is how you can think of dementia, it tits
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over from mild cognitive impairment to dementia. So for everyone
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who has dementia, there's another number being that same number
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that are not quite dementia but are on the way.
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So it's when you get to eighty five, your chances
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of having a completely normal, fully functioning brain, you're kind
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of down to around a third.
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Pretty slim chances.
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And of course we're talking about eighty five year olds
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but it normally shows up earlier than that, right, So
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at what point do we start seeing full blown kind
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of dementia.
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So if you get dementia before the age of sixty five,
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it's called early on set. It's unusual to get it
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before the age of sixty five. Most people will start
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to get it in their seventies and eighties. So that's
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the good news because a lot of my patients come
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and see me in their fifties and sixties and say,
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you know, I'm you know, I keep forgetting to turn
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up for coffee with my girlfriend. I think I've got dementia?
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Can you test me for it? So, you know, the
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good news is it's possible, it's unlikely.
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Yes, I think we have all experienced those forgetful moments.
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We've all had those, like I lose words all the time.
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And this is the thing, right, So you're obviously you
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are also known for your work around menopause, and this
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perimenopausal period affects your brain as well, and so we're
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constantly going is this something I should be worried about?
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Is this normal? Is this hormonal? Is that what you
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get as well? With your patients?
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One hundred percent, like we know that when it comes
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to pery menopause, which is your transition into menopause, proper
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eighty percent of women report brain pop. That is a
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ridiculous amount of brain pop. Like that is a ridiculous
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amount of lost brain hour. Amongst women our age, you
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were generally at the peak of their careers, trying to
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juggle like sick parents, a massive career, teenage children who
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are driving you not it's the peak time for divorce,
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and maybe you've got some sort of strain in your relationship,
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and then on top of that, you can't remember to
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go and do the shopping and to make a dinner. So,
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like there's a lot going on for women, and most
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of them think this is it. I'm at the start.
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I'm heading from here straight into dementia seamlessly. It's all
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downhill from here. And the good news is that by
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the time you hit menopause, for the vast majority of women,
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your brain will kind of sort itself out. It is
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really linked to a lot of the other symptoms of
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perry So it's kind of a lot to do with
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particularly insomnia and depression at this stage when you're in
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perimenopause and you're forgetting stuff and he's only a bit
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boggy in the brain, and you'll generally have like a
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nice little window of like amazing brain function until eventually
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you can slip into dementia, if that's what's going to happen.
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But for some women, for a small subset of women,
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it is the beginning to decline, and it is hard
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to know what's happening to you if you're in the
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middle of it.
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Yeah, what's the gender divide, Jenny? Does it affect one
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gender more than the other?
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Yeah? It looks sadly to mention as a women's issue,
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And we initially thought that because it's so common after
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the age of eighty, and more women live into their
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eighties than men. We just thought, listen, it's just because
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more women are living longer, and if you live long enough,
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you eventually get dementia. And that's why it's a women's
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issue rather than a men's issue, because they basically die
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off before they get an opportunity to get the dementia.
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But we know that there are estrogen and progesterone, so
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they're the two principal womens associated with reproduction in women.
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There are receptors for those all over the brain, particularly
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in the centers responsible for higher order thinking and for memory.
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We also know that estron and progesterone both directly act
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as neurotransmitters and heal the brain when it's got a
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brain injury. We also know, and this is really fascinating,
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that for women who go into menopause at forty seven,
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that's not very early. That's not even called early menopause.
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You know, because the average age of menopause in the
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UK and Australia is fifty fifty one. It's getting a
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little bit earlier as we get more migrants into both countries,
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but you know, generally around fifty one. But at forty
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seven that's not early. You know, we're for early menopause
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is forty five and below. But if you go into
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menopause at forty seven or earlier, you have a twenty
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percent higher risk of menopause. And we know that early
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menopause is a significant risk, which is a really interesting
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unless you go on HIT. So that's a super interesting fact.
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So it's definitely something to do with hormones. And so
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the natural question is should we just all go on
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hormone replacement therapy to prevent DEMNTA and the problem is
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we don't have a really good data on that. For
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those of us who hit menopause at kind of UBOLGS
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standard age, I'm fifty four, I haven't quite hit it yet.
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Is there any point in me going on HRT just
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to help my brain out a little bit? So I
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have a hit early menopause? And the evidence is a
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little bit mixed. Some studies have definitely shown that HRT
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does prevent dementia, but there are other studies that have
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actually shown the opposite. Really and in fact, you remember
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that really massive study the Women's Health Initiative. Now you
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might not remember that, but just as to jog everybody's memory,
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back in two thousand and two, there was this huge
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study and it was a really good study. They were
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looking to see whether hormone replacement therapy could prevent a
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whole raft of chronic diseases, but particularly heart disease. And
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so they took women who were an average age of
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sixty three, which I don't know about you, but I
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don't know anybody at sixty three who kind of needs
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to start HRTDN. They didn't ask some of our hot blushes.
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They just put them on either HRT in an old
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form that we don't use anymore, or a placebo, and
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they followed them up and after six years, what they've
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found was that for every ten thousand women who had
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a placebo that got thirty breast cancers, and for every
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ten thousand women who took HART they had SOWD thirty
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eight breast cancers, just thirty percent increased risk, huge but
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an almost a thirty percent increased risk, and they stopped
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the study. They also found slightly high risks of heart
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disease and also dementia in that study, and what they
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have worked out now is that it's all about timing.
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If you wait until your arteries have hardened and your
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body has got used to being without estrogen, and then
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you reintroduce it again, it does more hardening good. It
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looks like from most of the studies, certainly around heart disease,
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definitely around breast cancer, that if you just keep going
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as you hit menopause, you hit the ground money. If
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you start it within a couple of years and while
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your tissues are still soft, your arteries have not hardened yet,
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that in fact, in case of heart disease, it could
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potentially confer some benefits and the same with dementia is
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wow in terms of breast cancer risty, probably neutral. So
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that's just to explain everything that happens, you would. At
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this stage, we don't have the data that says every
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single one of us should go on HRT to prevent dementia,
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but that's possible. We're going to get there at some
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point because that's the way the data is kind of
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heading right now.
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So interesting those of us who have a family member
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like my husband, so my mother in law died of Alzheimer's. Oh, well,
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before we go there, there are different types of dementia.
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We all think about Alzheimer's.
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Is it worth discussing all the different kinds or is
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that really not that relevant?
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We don't do it anymore. And I'll tell you why.
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The way to diagnose the different forms of dementia, and
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there are lots of them, and I've sort of addressed
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them in my book, and I've diffected them all at
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his Parkinson's disease and his lowy body dementia and vascular
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and his But what they've done in autopsy studies is
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that they look to people with Alzheimer's disease and you
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can kind of see Alzheimer's disease. On certain scans, if
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you do an autopsy of them, seventy five percent of
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them also have vascular dementia. But what we know is
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that if you add two types of dementia together, one
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plus one equals more dementia, worse dementia, earlier dementia. And
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in a way, as terrible as that sounds, it's kind
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of good news because that's the stuff you can prevent
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the vascular dementia. Which is what I need by that
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is you've actually damaged your arteries and supply your brain
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all of the nutrients it needs, the beautiful blood, their
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fresh fluids, your nutrients, your oxygen. If you damage those
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arteries so you start your brain, that actually causes untold
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damage to your brain and makes your Alzheimer's worse. Well,
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happy days. We can actually prevent that stuff. That is
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the really good news. The big thing that I think
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what happy to crappy want to know is it's all
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about what you do now. If you wait till you're
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seventy five to start trying to take the trains on
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a different track, you have totally missed that boat. I mean,
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it's sort of never too late to start trying to
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get healthier. Don't get me wrong, But if you really
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want banks to your buck, if you really want to
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prevent dementia, it's what you do in your forties and fifties.
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Then it's just going to make all of the difference.
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And we don't think about it enough, but we've got
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to start. We've got to start doing this now, and
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for free. I'm going to chuck in better mental health,
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less heart attacks, less cancer, you know, so many other
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things that we're going to chuck in for free, less diabetes,
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better wait control, all the things that matter to us,
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for the same price as preventing dementia. Like it's such